Crème fraîche is great with just about everything. Consider serving it with smoked salmon or using it to thicken pan sauces. Try replacing some butter in mashed potatoes with a bit of crême fraîche. Add a dollop to soup, stew, or stir-fried vegetables.
Any place you use heavy cream, sour cream, cream cheese, or even butter, use crême fraîche as a partial or full replacement. You can't go wrong!